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E-Journal of Chemistry
Volume 8, Issue 2, Pages 547-552

One-Pot Synthesis of Tetrasubstituted Imidazoles Catalyzed by Preyssler-Type Heteropoly Acid

Ali Javid,1 Majid M. Heravi,2 F. F. Bamoharram,3 and Mohsen Nikpour1

1Department of Chemistry, School of SciencesIslamic Azad University, Ahvaz Branch, Ahvaz 6134968875, Iran
2Department of Chemistry Azzahra University, Vanak, Tehran, Iran
3Department of Chemistry, School of SciencesIslamic Azad University, Mashhad Branch, Mashhad, Iran

Received 27 June 2010; Accepted 2 September 2010

Copyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A simple one-pot four-component synthetic method was reported for the preparation of tetrasubstituted imidazole derivatives from benzil, aromatic aldehydes, primary amines and ammonium acetate in the presence of Preyssler-type heteropoly acid catalyst. This method was proved to be eco-benign, easy work-up, convenient, relatively short reaction times and the products were isolated with high yields.