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E-Journal of Chemistry
Volume 9 (2012), Issue 4, Pages 1676-1682

Synthesis of Novel N1 and N2 Indazole Derivatives

1Research Centre, Department of Chemistry, Chaitanya P. G. College, Warangal-506 004, A. P., India
2Department of Chemistry, National Institute of Technology, Warangal-506 004, A.P., India

Received 21 August 2011; Accepted 27 October 2011

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The alkylation of 5-cyano indazoles 2 in the presence of readily available imidizolium salts (ionic liquids) (Bmim)BF4 as phase transfer catalyst were performed to afford the regio isomers N1-and N2-(substituted alkyl)-5-cyano indazoles. The N1-alkylated cyano indazoles were converted to the corresponding N1-(substituted alkyl)-5-aminomethyl and 5-carbaldehydes 5(a-f) and 6(a-f).