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E-Journal of Chemistry
Volume 9 (2012), Issue 4, Pages 1951-1959

Study on the Interaction of Serum Albumin and Micromolecule Compounds

1College of Bioengineering, Chongqing University, Chongqing 400044, China
2College of Criminal Investigation Law, Southwest University of Political Science and Law, Chongqing 401120, China
3College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044, China

Received 9 July 2011; Accepted 20 September 2011

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Fluorescence spectrometry is a classical and conventional technique widely used in interaction investigation, which takes serum albumin as the fluorescence source while micro-molecule compound as the quencher. With analyzing the properties of serum albumin and its amino acids, deficiencies in the conventional fluorescence spectrometry became obvious: information expressed by the conventional technique was not sufficient to represent the entire interaction. In consideration of that, a new method was proposed to improve the conventional one. Intercompared the experimental results of those two methods, defects of the conventional fluorescence spectrometry were noticeable. In addition, molecular docking simulation and binding force investigation also manifested the same as above.