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E-Journal of Chemistry
Volume 9, Issue 1, Pages 113-120
http://dx.doi.org/10.1155/2012/327351

Synthesis, Isolation and Characterization of Process-Related Impurities in Oseltamivir Phosphate

Yogesh Kumar Sharma,1 Dau Dayal Agarwal,2 Sudesh Bhure,2 Sanjay Singh Rathore,2 Chakravir Rawat,2 and Rajendranath Mukharjee2

1Department of Industrial Chemistry, Jiwaji University, Gwalior-475011, Madhya Pradesh, India
2Pharmasolve Specialities (I) Pvt. Ltd., Mumbai, India

Received 28 May 2011; Accepted 21 July 2011

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Three known impurities in oseltamivir phosphate bulk drug at level 0.1% (ranging from 0.05-0.1%) were detected by gradient reverse phase high performance liquid chromatography. These impurities were preliminarily identified by the mass number of the impurities. Different experiments were conducted and finally the known impurities were synthesized and characterized.