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Gholam Hossein Mahdavinia, Maryam Mirzazadeh, "Fast, Facile and Convenient Synthesis of α,α-Bis(substituted-arylidene) Cycloalkanones: An improved Protocol", Journal of Chemistry, vol. 9, Article ID 390528, 6 pages, 2012. https://doi.org/10.1155/2012/390528
Fast, Facile and Convenient Synthesis of α,α-Bis(substituted-arylidene) Cycloalkanones: An improved Protocol
Abstract
Commercially available potassium hydroxide (KOH), a simple base, was found to be a catalyst for tandem cross-aldol condensation between cyclic ketones and aromatic aldehydes leading to a fast and easy synthesis of α,α-bis (substituted-arylidene) cycloalkanones in the shortest times of all previous methods. The reaction of aryl aldehydes with five and six-membered cyclic ketones afforded excellent yields after few seconds in most cases. The reaction conditions were compatible with various electron withdrawing and electron donating substituents, e.g. Cl, F, NO2, OMe, Me and NMe2.
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Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
