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Fast, Facile and Convenient Synthesis of α,α-Bis(substituted-arylidene) Cycloalkanones: An improved Protocol
Gholam Hossein Mahdavinia
1 and Maryam Mirzazadeh21Department of Chemistry, Islamic Azad University-Marvdasht Branch, Marvdasht, Iran
2Department of Chemistry, Islamic Azad University-Firoozabad Branch, Fars, Iran
Abstract
Commercially available potassium hydroxide (KOH), a simple base, was found to be a catalyst for tandem cross-aldol condensation between cyclic ketones and aromatic aldehydes leading to a fast and easy synthesis of α,α-bis (substituted-arylidene) cycloalkanones in the shortest times of all previous methods. The reaction of aryl aldehydes with five and six-membered cyclic ketones afforded excellent yields after few seconds in most cases. The reaction conditions were compatible with various electron withdrawing and electron donating substituents, e.g. Cl, F, NO2, OMe, Me and NMe2.
Copyright
Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
