Ashvin D. Panchal, Pravinkumar M. Patel, "Synthesis, Anti-Bacterial and Anti-Fungal Evaluation of Pyrazoline Derivatives", Journal of Chemistry, vol. 9, Article ID 458035, 9 pages, 2012. https://doi.org/10.1155/2012/458035
Synthesis, Anti-Bacterial and Anti-Fungal Evaluation of Pyrazoline Derivatives
The Series of N-(5-(Substituted phenyl)-4,5-dihydro-1H-pyrazol-3-yl)-4H-1,2,4-triazol-4-amine compounds were prepared by reaction of 4-amino-1,2,4-Triazole with Acetyl Chloride followed by different aromatic aldehydes and cyclization with hydrazine hydrate. The structures of new compounds were confirmed by IR and 1H-NMR spectral data. Anti-bacterial and Anti-fungal activities were evaluated and compared with the standard drugs, some compounds of the series exhibited promising anti-microbial and anti-fungal activity compared to standard drugs.
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