Journal of Chemistry

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Journal of Chemistry / 2012 / Article

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Volume 9 |Article ID 476989 | 6 pages | https://doi.org/10.1155/2012/476989

Synthesis and Analgesic Studies of Some New 2-pyrazolines

S. Sridhar1 and Y. Rajendraprasad2

1Department of Pharmaceutical Chemistry, Malla Reddy College of Pharmacy, Secunderabad, India

2University College of Pharmaceutical Sciences, Andhra University, Vishakapatanam, India

Received07 Jul 2011
Accepted20 Sep 2011

Abstract

A new series of 2-pyrazolines (4a-j) were synthesized by reacting chalcones (3a-j) with phenyl hydrazine in the presence of pyridine and ethanol. All these compounds were characterized by means of their IR, 1H-NMR spectral data and microanalyses. When these compounds were evaluated for analgesic activity, some of them were found to possess significant activity, when compared to standard drugs.

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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