Journal of Chemistry

Journal of Chemistry / 2012 / Article

Open Access

Volume 9 |Article ID 481682 | https://doi.org/10.1155/2012/481682

M. Deepa, V. Harinadha Babu, R. Parameshwar, B. Madhava Reddy, "Synthesis of 3-(1, 3-Diphenyl-1H-pyrazol-4-yl) Propanoic Acids Using Diimide Reduction", Journal of Chemistry, vol. 9, Article ID 481682, 5 pages, 2012. https://doi.org/10.1155/2012/481682

Synthesis of 3-(1, 3-Diphenyl-1H-pyrazol-4-yl) Propanoic Acids Using Diimide Reduction

Received02 Jul 2011
Accepted27 Aug 2011

Abstract

Pyrazole-1H-4-yl-acrylic acids (3a-j) were prepared from pyrazole-1H-4-carbaldehydes which in turn were prepared by the Vilsmeier-Haack reaction of phenyl hydrazone derivatives (1a-j). The reaction of pyrazole-1H-4-yl-acrylic acids to 3-(1, 3-diphenyl-1H-pyrazol-4-yl) propanoic acids (4a-j) was carried out using Pd-charcoal and diimide methods and % yields were compared. Though the yields may be slightly less in diimide method, the method was found to be economical, highly effective with simple operating procedure.

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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