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E-Journal of Chemistry
Volume 9, Issue 3, Pages 1407-1411
http://dx.doi.org/10.1155/2012/502125

RP-HPLC Estimation of Trospium Chloride in Tablet Dosage Forms

1Bapatla College of Pharmacy, Bapatla- 522 101, A.P., India
2A. U. College of Pharmaceutical Sciences, Visakhapatnam-530 003, A.P., India
3V.V. Institute of Pharmaceutical Sciences, Gudlavalleru-521 356, A.P., India

Received 13 September 2011; Accepted 11 November 2011

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A rapid, sensitive and precise HPLC method was developed for the estimation of trospium chloride in pure and tablet dosage forms. Seperation of the drug was achieved on a reverse phase Azilent C18 column using a mobile phase consisting of phosphate buffer and acetonitrile in the ratio of 60:40v/v. The flow rate was 1 ml/min and the detection wave length 215 nm. The linearity was found in the range of 10-150 μg/ml with a correlation coefficient of 1.0000. The proposed method was validated for its sensitivity, linearity, accuracy and precision. This method was employed for routine quality control analysis of trospium chloride in tablet dosage forms.