Journal of Chemistry

Journal of Chemistry / 2012 / Article

Open Access

Volume 9 |Article ID 638452 | 9 pages | https://doi.org/10.1155/2012/638452

A Facile Synthesis and Studies of Some New Chalcones and Their Derivatives Based on Heterocyclic Ring

Received01 Nov 2011
Accepted07 Jan 2012

Abstract

Chalcones (6a-f) have been prepared by the condensation of ketone (5) and different aromatic and heterocyclic aldehydes. These chalcones (6a-f) on treatment with guanidine hydrochloride and phenyl hydrazine hydrochloride in presence of alkali give aminopyrimidines (7a-f) and phenylpyrazolines (8a-f) respectively. All the newly synthesized compounds have been characterized on the basis of IR, 1HNMR spectral data as well as physical data. Antibacterial activity (minimum inhibitory concentration MIC) against Gram-positive S. aureus MTCC 96 and S. pyogeneus MTCC 442 and Gram-negative P. aeruginosa MTCC 1688 and E. coli MTCC 443 bacteria, as well as antifungal acivities (MIC) against C. albicans MTCC 227, A. niger MTCC 282 and A. clavatus MTCC 1323 were determined by broth dilution method.

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


More related articles

426 Views | 2349 Downloads | 3 Citations
 PDF  Download Citation  Citation
 Order printed copiesOrder

Related articles

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at help@hindawi.com to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19. Sign up here as a reviewer to help fast-track new submissions.