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E-Journal of Chemistry
Volume 9 (2012), Issue 1, Pages 407-414

An Efficient One-Pot Synthesis of 1, 5-Benzodiazepine Derivatives Catalyzed by TBAB under Mild Conditions

Mohammad A. Baseer1 and Asgar Jafar Khan2

1Organic Chemistry Research Laboratory, Yeshwant Mahavidyalaya, Nanded-431602, India
2Laboratory of Organic Synthesis, Milliya College, Beed-431122, India

Received 18 June 2010; Accepted 1 March 2011

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


2,3-Dihydro-1H-1,5-benzodiazepines were synthesized by reaction of o-phenylenediamine with ketones (acyclic / cyclic) under solvent free conditions in the presence of tetra butyl ammonium bromide (TBAB) in short reaction time with excellent yield.