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E-Journal of Chemistry
Volume 9, Issue 1, Pages 89-92

Spectrophotometric Determination of Zidovudine in Pharmaceutical Dosage Forms

J. Sudhakar Reddy,1 MD. S. Maqsood Ahmed,1 I. E. Chakravarthy,2 and K. Prabhavathi3

1Department of chemistry, Osmania College, Kurnool-518001, A. P, India
2Department of Chemistry, Rayalaseema University, Kurnool-518002, A. P, India
3Department of Chemistry, S. B. S.Y. M. Degree College, Kurnool-518004, A. P, India

Received 13 May 2011; Accepted 31 July 2011

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A simple, sensitive and economical spectrophotometric method has been developed for the determination of zidovudine in commercial dosage forms. The method was based on the formation of chloroform extractable complex of zidovudine with wool fast blue. The absorbance of the extractable ion pair complex is measured at the wavelength of maximum absorbance 590 nm against the reagent blank treated similarly. Statistical analysis proves that the proposed methods are reproducible and selective for the estimation of zidovudine in bulk drug and in its tablet dosage form.