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E-Journal of Chemistry
Volume 9 (2012), Issue 4, Pages 2239-2244

A Facile Synthesis of Polysubstituted Pyrroles by One-Pot Three-Component Reaction

1Department of Chemistry, Mahshahr Branch, Islamic Azad University, Mahshahr, Iran
2Department of Chemistry, Islamic Azad University, Yazd Branch, P.O. Box 89195-155, Yazd, Iran

Received 28 October 2011; Accepted 29 December 2011

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A new and efficient one-pot synthesis of polysubstituted pyrrole derivatives by three-component reaction between dialkyl acetylenedicarboxylates, triphenylphosphine, 2-aminopyridin derivatives in the presence of arylglyoxals is described. The reactions were performed in dichloromethane at room temperature and neutral conditions and afforded high yields of products.