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E-Journal of Chemistry
Volume 9 (2012), Issue 4, Pages 1919-1928

3D-Metal Complexes Derived from Proton Pump Inhibitors-Synthesis, Characterization and Biological Studies

1Sadhu Vaswani College Bairagarh, Department of Chemistry, Bhopal 462030, India
2University of Pitesti, Department of Physics and Chemistry, Pitesti 110040, Romania

Received 19 December 2011; Accepted 21 February 2012

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Complexes of lansoprazole 2[[[[3-methyl, 4-(2′,2′,2′-trifluoro-ethoxy)]-2-pyridinyl] methyl]sulfonyl]–1H–benzimidazole (LAN) with chlorides of Co(II), Ni(II), Cu(II), Mn(II) and Zn(II) were synthesized. LAN is a weak base and it can form several complexes with transition and non-transition metal ions. It should be noticed that the reaction of all the metal salts yielded bis(ligand) complexes of the general formula [ML2(H2O)2] and [ML2] (M = Co, Ni, Cu, Mn and Zn). The complexes were characterized by elemental analysis, molar conductivity, magnetic susceptibility measurements, IR, 1H-NMR, UV-visible spectral studies, ESR, SEM, x-ray diffraction, TGA and mass spectra. In all the complexes ligand is coordinated by participation of the pyridine nitrogen of the benzimidazole ring and sulphonyl group. Electronic spectra and magnetic susceptibility reveal octahedral geometry for Mn(II), Co(II), Ni(II) and Cu(II) complexes and tetrahedral for Zn(II) complex. The antimicrobial activity of the ligand and its complexes against bacteria Pseudomonas aeruginosa, Staphylococcus aureus and fungi Aspergillus niger and Aspergillus flavous were investigated. The effect of metals on the antimicrobial activity of the ligand has been discussed.