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Journal of Chemistry
Volume 2013, Article ID 107302, 9 pages
http://dx.doi.org/10.1155/2013/107302
Research Article

Design, Synthesis, and Acetylcholinesterase Inhibition Assay of Novel 9-(1-(Substituted-benzyl)piperidin-4-yl)-2-chloro-9H-purin-6-amine Derivatives

1Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Jinan, Shandong 250012, China
2Department of Pharmacology, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Jinan, Shandong 250012, China

Received 22 May 2013; Revised 9 August 2013; Accepted 13 August 2013

Academic Editor: Marco Radi

Copyright © 2013 Dongwei Kang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A new series of 9-(1-(substituted-benzyl)piperidin-4-yl)-2-chloro-9H-purin-6-amine derivatives were designed, synthesized, and characterized on the basis of 1H-NMR, 13C-NMR, and mass spectra. The newly synthesized compounds were evaluated for the inhibition activity against acetylcholinesterase (AChE). Biological results revealed that four compounds among them showed moderate activities against AChE with inhibitory percentage more than 10% at 100 μM. Further pharmacology investigation towards other pathological routes in AD is currently underway.