Design, Synthesis, and Acetylcholinesterase Inhibition Assay of Novel 9-(1-(Substituted-benzyl)piperidin-4-yl)-2-chloro-9<i>H</i>-purin-6-amine Derivatives

<table><i>Reagents and Conditions.</i> (i) <i>t</i>-BuOH, Et<sub>3</sub>N; (ii): methanesulfonyl chloride (MsCl), DCM, Et<sub>3</sub>N, and  4-DMAP; (iii) NaH, DMF; (iv): TFA, DCM; (v) substituted benzyl chloride (bromine, fluorine), DMF, and K<sub>2</sub>CO<sub>3</sub>.</table>

Journal of Chemistry

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Scheme 1

Scheme 1: Design, Synthesis, and Acetylcholinesterase Inhibition Assay of Novel 9-(1-(Substituted-benzyl)piperidin-4-yl)-2-chloro-9<i>H</i>-purin-6-amine Derivatives 

Scheme 1 | Design, Synthesis, and Acetylcholinesterase Inhibition Assay of Novel 9-(1-(Substituted-benzyl)piperidin-4-yl)-2-chloro-9H-purin-6-amine Derivatives 