Table of Contents Author Guidelines Submit a Manuscript
Journal of Chemistry
Volume 2013, Article ID 147565, 5 pages
http://dx.doi.org/10.1155/2013/147565
Research Article

Synthesis and Antibacterial, Antimycobacterial Activity of 7-[4-{5-(2-Oxo-2-p-substituted-phenylethylthio)-1,3,4-thiadiazol-2yl}-3′-methylpiperazinyl] Quinolone Derivatives

1Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education & Research, Shirpur, Dhule District, Shirpvr 425405, India
2Department of Pharmaceutical Chemistry, Nashik Gramin Shikshan Prasarak Mandal's College of Pharmacy, Triambak Road, Anjaneri, Nashik 422213, India

Received 30 December 2011; Revised 6 May 2012; Accepted 16 May 2012

Academic Editor: Alessandro Volonterio

Copyright © 2013 Kapil M. Agrawal and Gokul S. Talele. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Rustomjee, C. Lienhardt, T. Kanyok et al., “A phase II study of the sterilising activities of ofloxacin, gatifloxacin and moxifloxacin in pulmonary tuberculosis,” International Journal of Tuberculosis and Lung Disease, vol. 12, no. 2, pp. 128–138, 2008. View at Google Scholar · View at Scopus
  2. M. B. Conde, A. Efron, C. Loredo et al., “Moxifloxacin versus ethambutol in the initial treatment of tuberculosis: a double-blind, randomised, controlled phase II trial,” The Lancet, vol. 373, no. 9670, pp. 1183–1189, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. S. E. Dorman, J. L. Johnson, S. Goldberg et al., “Substitution of moxifloxacin for isoniazid during intensive phase treatment of pulmonary tuberculosis,” American Journal of Respiratory and Critical Care Medicine, vol. 180, no. 3, pp. 273–280, 2009. View at Google Scholar · View at Scopus
  4. WHO/HTM/TB/2008, 402, 2008, Emergency Update 2008.
  5. A. Foroumadi, S. Emami, A. Hassanzadeh et al., “Synthesis and antibacterial activity of N-(5-benzylthio-1,3,4-thiadiazol-2- yl) and N-(5-benzylsulfonyl-1,3,4-thiadiazol-2-yl)piperazinyl quinolone derivatives,” Bioorganic and Medicinal Chemistry Letters, vol. 15, no. 20, pp. 4488–4492, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. J. P. Sanchez, J. M. Domagala, S. E. Hagen et al., “Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids,” Journal of Medicinal Chemistry, vol. 31, no. 5, pp. 983–991, 1988. View at Google Scholar · View at Scopus
  7. D. T. W. Chu, P. B. Fernandes, A. K. Claiborne et al., “Synthesis and structure-activity relationships of novel arylfluoroquinolone antibacterial agents,” Journal of Medicinal Chemistry, vol. 28, no. 11, pp. 1558–1564, 1985. View at Google Scholar · View at Scopus
  8. L. L. Shen, L. A. Mitscher, P. N. Sharma et al., “Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug-DNA binding model,” Biochemistry, vol. 28, no. 9, pp. 3886–3894, 1989. View at Google Scholar · View at Scopus
  9. A. Rattan, A. Kalia, and N. Ahmad, “Multidrug-resistant Mycobacterium tuberculosis: molecular perspectives,” Emerging Infectious Diseases, vol. 4, no. 2, pp. 195–209, 1998. View at Google Scholar · View at Scopus
  10. Organic Syntheses, Coll, R. M. Cowper, L. H. Davidson, and A. H. Blatt, Eds., vol. 2, pp. 480–481, John Wiley & Sons, New York, NY, USA, 1943.
  11. Organic Syntheses, Coll, G. H. Coleman, G. E. Honeywell, and A. H. Blatt, Eds., vol. 2, pp. 443–445, John Wiley & Sons, New York, NY, USA, 1943.
  12. S. Goto, H. Sakamoto, and M. Ogawa, “Bactericidal activity of cefazolin, cefoxitin, and cefmetazole against Escherichia coli and Klebsiella pneumoniae,” Chemotherapy, vol. 28, no. 1, pp. 18–25, 1982. View at Google Scholar · View at Scopus
  13. W. J. Suling, L. E. Seitz, V. Pathak et al., “Antimycobacterial activities of 2,4-diamino-5-deazapteridine derivatives and effects on mycobacterial dihydrofolate reductase,” Antimicrobial Agents and Chemotherapy, vol. 44, no. 10, pp. 2784–2793, 2000. View at Publisher · View at Google Scholar · View at Scopus
  14. D. M. Yajko, J. J. Madej, M. V. Lancaster et al., “Colorimetric method for determining MICs of antimicrobial agents for Mycobacterium tuberculosis,” Journal of Clinical Microbiology, vol. 33, no. 9, pp. 2324–2327, 1995. View at Google Scholar · View at Scopus
  15. D. Sriram, P. Yogeeswari, and S. P. Reddy, “Synthesis of pyrazinamide Mannich bases and its antitubercular properties,” Bioorganic and Medicinal Chemistry Letters, vol. 16, no. 8, pp. 2113–2116, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. R. T. Morrison and R. N. Boyd, Organic Chemistry, Pearson Education, New Delhi, India, 2004.