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Journal of Chemistry
Volume 2013, Article ID 148412, 9 pages
Research Article

Synthesis and Antimicrobial and Antioxidant Activities of Some New 5-(2-Methyl-1H-indol-3-yl)-1,3,4-oxadiazol-2-amine Derivatives

1Department of Post-Graduate Studies and Research in Chemistry, Gulbarga University, Gulbarga 585 106, India
2Shri Prabhu Arts, Science & J. M. Bohra Commerce Degree College, Shorapur, Karnataka 585 224, India

Received 31 May 2013; Revised 18 August 2013; Accepted 9 September 2013

Academic Editor: Jose Alberto Pereira

Copyright © 2013 Anand R. Saundane et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A series of 5-(2-methyl-1H-indol-3-yl)-1,3,4-oxadiazol-2-amine derivatives (3–5) were synthesized. These previously unknown compounds were characterized by spectral studies and elemental analysis. These compounds were evaluated for their antimicrobial and antioxidant activities. Among all the compounds tested 5d exhibited promising antibacterial, antifungal, radical scavenging, and ferric ions (Fe3+) reducing antioxidant power (FRAP) activities, whereas the compounds 3b, 4c, and 5e exhibited good FRAP and metal chelating activities. In general compounds containing chloro and methyl substituent exhibited better antimicrobial and antioxidant activities.