Synthesis of 2,3-Dihydro-6-methyl-2-thiopyrimidin-4(1H)-one (6-Methylthiouracil) Derivatives and Their Reactions

Table 1

The physicochemical characteristics of synthesized derivatives of 2,3-dihydro-6-methyl-2-thioxopyrimidin-(1H)-one, (I–IX).

Products	Yields %	Temp mp, °C	Elemental analysis
			Mol. formula	Calculated/found, %
				C	H	N	S
I	64	235	C5H6N2OS	42.53	4.03	19.54	22.76
				42.25	4.23	19.72	22.54
II	61.5	220	C7H8N2O3S	41.03	4.04	14.11	16.01
				42	4	14	16
III	80	270	C14H16N4O6S2Cu	36.47	3.23	12.34	13.52
				36.36	3.03	12.12	13.85
IV	69	210	C7H10N2O2S	45.02	5.54	15.28	16.89
				45.16	5.38	15.05	17.20
V	44	200	C8H11N2O2SCl	40.72	4.81	11.75	13.84
				40.94	4.69	11.94	13.65
VI	100	340	C5H5N2OSNa	36.28	3.23	17.29	19.28
				36.59	3.05	17.07	19.51
VII	67	210	C8H10N2O2S	48.22	5.16	14.35	16.47
				48.48	4.05	14.14	16.16
VIII	63.5	240	C7H8N2O2S	45.36	4.63	15.03	17.55
				45.65	4.35	15.22	17.39
IX	57.3	215	C12H10N2O2S	58.72	4.18	11.4	13.25
				58.54	4.07	11.38	13.01