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Journal of Chemistry
Volume 2013, Article ID 183130, 7 pages
Research Article

Synthesis and Microbial Activity of Novel 3-Methyl-2-pyrazolin-5-one Derivatives

1Chemistry Department, Faculty of Science, Jazan University, P.O. Box 2079, Saudi Arabia
2Riyadh Community College, King Saud University, P.O. Box 28095, Riyadh 11437, Saudi Arabia
3Department of Chemical Engineering, College of Engineering, King Saud University, P.O. Box 800, Riyadh 11421, Saudi Arabia

Received 18 December 2012; Revised 14 March 2013; Accepted 27 March 2013

Academic Editor: Philippe Jeandet

Copyright © 2013 Mohamed S. Mostafa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


2-Oxo-2H-chromene-3-carbohydrazide derivatives 2a,b react with 2-{[4-(substituted thiazol-2-yl)iminoethyl)-phenyl]hydrazono}-3-oxo-butyric acid ethyl esters 4ac to give 3-methyl-1-[(2-oxo-2H-chromen-3-yl) carbonyl]-4-{[4-(substituted thiazol-2-yl)iminoethyl)-phenyl]hydrazono}]-2-pyrazolin-5-one derivatives 5af. A considerable increase in the reaction rate had been observed with better yield using microwave irradiation for the synthesis of compounds 2a, b, 3ac, and 5af. The synthesized products were tested against B. subtilis, S. aureus, and E. coli as well as C. albicans compared with tetracycline and nystatin as reference drugs.