Synthesis and Microbial Activity of Novel 3-Methyl-2-pyrazolin-5-one Derivatives

Table 1

Characterization data of synthesized compounds.

Comp	M.P. (°C)	Solvent of crystn.	Yield (%)	Formula (M.W.)	Analysis calcd./found
					C	H	N	S
2a	144–146	Ethanol	75	C10H8N2O3	58.82	3.95	13.71	—
				(204.185)	58.81	3.97	13.75	—
2b	210–212	Ethanol	60	C10H7BrN2O3	42.43	2.49	9.89	—
				(283.081)	42.48	2.46	9.91	—
3a [23]	201–204	Ethanol	62	C11H11N3S	60.80	5.10	19.33	14.75
				(217.29)	60.81	5.13	19.38	14.71
3b	230–232	Ethanol	58	C12H13N3S	62.85	5.71	18.32	13.98
				(229.301)	62.86	5.73	18.37	14.01
3c	271–273	EtOH-H2O	50	C15H13N3S	67.38	4.90	15.71	11.99
				(267.35)	67.40	4.91	15.69	11.96
4a [23]	165–167	Ethanol	66	C17H18N4O3S	56.96	5.06	15.63	8.94
				(358.416)	56.98	5.04	15.67	8.98
4b	186–188	Ethanol	62	C18H20N4O3S	58.04	5.41	15.04	8.60
				(372.443)	58.09	5.40	15.07	8.66
4c	140–142	Ethanol	60	C21H20N4O3S	61.74	4.93	13.71	7.84
				(408.476)	61.78	4.96	13.69	7.88
5a	208–210	Ethanol	60	C25H18N6O4S	60.23	3.63	16.85	6.43
				(498.517)	60.20	3.66	16.80	6.47
5b	232–234	Ethanol	54	C26H20N6O4S	60.92	3.93	16.39	6.25
				(512.544)	60.94	3.98	16.42	6.30
5c	222–224	DMF	57	C29H20N6O4S	63.49	3.67	15.32	5.84
				(548.577)	63.51	3.62	15.38	5.88
5d	280–282	DMF	50	C25H17BrN6O4S	52.00	2.96	14.55	5.55
				(577.413)	52.08	3.99	14.51	5.59
5e	250–252	DMF	48	C26H19BrN6O4S	52.80	3.23	14.20	5.42
				(591.44)	52.78	3.20	14.28	5.45
5f	264–267	Pet-ether	37	C29H19BrN6O4S	55.51	3.05	13.39	5.10
				(627.473)	55.50	3.03	13.41	5.12