Review Article

An Overview of Analytical Determination of Diltiazem, Cimetidine, Ranitidine, and Famotidine by UV Spectrophotometry and HPLC Technique

Table 2

Application of HPLC to the determination of diltiazem.

ColumnMobile phasenmRef.

50 × 4.6 mm; 1.8 μm; Zorbax SB-PhenylACN : water (60 : 40) + 1 Ml
Trifluoroacetic acid
238[50]
Hypersil, ODS, C-18 (150 × 4.6 mm, 5 micron)Methanol : water (80 : 20 v/v, pH 3.1)236[51]
C18 Bondapak RP columnMeCN and 0.05 M KH2PO4237[52]
Spherisorb S5W,MeOH-CH2Cl2-hexane237 [58]
Short alkyl chain, silanol-deactivated columnMethanol : buffer (50 : 50)237 [59]
C18-bonded silica gelMethanol : phosphate buffer-diethyl amine237 [60]
Stainless steel, Bondapak-C1810 m column Methanol : TEMED (0.8%, pH 5.4), 60 : 40 (vol/vol)238 [61]
Spherisorb C18 columnMethanol-water triethylamine239[67]
C18-reversed phase column, Bondapak, 10 m silica, 300 (3.9 mm I.D.)Methanol-acetonitrile-0.04 M ammonium Bromide-triethyl ammine (40 : 24 : 36 : 0.06), pH < 6.4237[68]
5  m Lichrocart Lichrospher 60 RP-select BAcetonitrile 0.025 molL−1 KH2PO4 35 : 64 (v/v), 5.5 pH215[74]
A 15 cm × 4.1 mm, pH-stable (pH 1–13) polymeric reverse phase columnMeCN-0.01 M tetrabutyl-ammonium hydroxide (60 : 40, v/v)254 [75]
Hiber, 250-4.6 RP-18 columnACN : water (85 : 15 v/v, pH 2.6 ± 0.02)230[80]
Kromasil C18 column (300 mm × 4 mm i.d., 10 μm particle size) Methanol : water (90 : 10 v/v).237[81]
Hiber, 250-4.6 RP-18 columnACN : methanol : water (30 : 20 : 50, v/v, pH 2.59 ± 0.02)230[82]
Hiber RT 250-4.6 Purospher Star RP-18 columnMethanol : water, 80 : 20 (v/v, pH 3.1 ± 0.02)240[83]
Hiber, RP-18 column ACN : methanol : water (30 : 20 : 50 v/v, pH 3.6)230[84]
Nuclosil 100-10 C-18 (250 × 4.6 mm)ACN : methanol : water (10 : 55 : 35 v/v, pH 2.65 ± 0.02)240[85]
Purospher STAR RP-18 end capped (5  m)Methanol : water (60 : 40 v/v) with pH 3.9230[86]
Spherisorb S5W silica column10 mM ammonium perchlorate in MeOH pH 7.6240 [97]
Radial-PAK CN column0.06 M KH2PO4-MeOH-Et3N (55 : 45 : 0 : 25)237 [98]
Nucleosil C-18 columnAcetonitrile-0.1 M NH4H2PO4 (37 : 63) 237 [100]
Cyanopropylsilane, RP column Acetonitrile-phosphate buffer triethylamine (pH 3.5)237 [101]
Supelcosil LC-8-DB columnMeOH-0.05 M phosphate buffer pH 5.0 (1 : 1)237 [102]
μ-Bondapak CN RP column0.01 M Na phosphate buffer (pH 5.0)-MeOH-diethylamine (55 : 45 : 0.5)254 [109]