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Journal of Chemistry
Volume 2013, Article ID 240381, 8 pages
http://dx.doi.org/10.1155/2013/240381
Research Article

Preparation of New α-Aminophosphonate Derivatives by Kabachnik-Fields Reaction Using a Recyclable Catalyst

Department of Chemistry, Sahyadri Science College (Autonomous), Shimoga, Karnataka 577203, India

Received 21 May 2013; Revised 29 June 2013; Accepted 29 June 2013

Academic Editor: John CG Zhao

Copyright © 2013 Nellisara D. Shashikumar. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A convenient and efficient synthetic method for the preparation of some new α-aminophosphonate derivatives via a one-pot three-component system has been achieved using Amberlite IRC-748 as a recyclable catalyst. This method not only provides an excellent complement for the synthesis of α-aminophosphonates but also avoids the use of hazardous acids or expensive/toxic Lewis acids and harsh reaction conditions. Most of the synthesized compounds (4a–o) exhibited activity against bacteria/fungi strains and moderate DPPH radical scavenging activity.