Acetylation of Phenols, Anilines, and Thiols Using Silica Sulfuric Acid under Solvent-Free Conditions

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td align="left">Entry</td><td align="center">Reagent</td><td align="center">A : B (mole ratio)</td><td align="center">Time (min)</td><td align="center">Yield %</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td align="left">1</td><td align="center">CH<sub>3</sub>CO<sub>2</sub>Et</td><td align="center">1.0 : 2.0</td><td align="center">10</td><td align="center">0</td></tr><tr><td align="left">2</td><td align="center">CH<sub>3</sub>CO<sub>2</sub>H</td><td align="center">1.0 : 2.0</td><td align="center">10</td><td align="center">0</td></tr><tr><td align="left">3</td><td align="center">Vinyl acetate</td><td align="center">1.0 : 2.0</td><td align="center">10</td><td align="center">20</td></tr><tr><td align="left">4</td><td align="center">CH<sub>3</sub>COCl</td><td align="center">1.0 : 2.0</td><td align="center">10</td><td align="center">95</td></tr><tr><td align="left">5</td><td align="center">(CH<sub>3</sub>CO)<sub>2</sub>O</td><td align="center">1.0 : 2.0</td><td align="center">3</td><td align="center">98</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Acylation of 4-chloroaniline (A) by different acylating reagents (B) with SSA under solvent-free conditions at room temperature.

Journal of Chemistry

tab2

Table 2

Table 2: Acetylation of Phenols, Anilines, and Thiols Using Silica Sulfuric Acid under Solvent-Free Conditions 