Research Article
Synthesis and Antifungal Studies of (2E)-N-Benzyl-N′-phenylbut-2-enediamide and (2E)-N,N′-Dibenzylbut-2-enediamide Analogues
Table 1
Antifungal activity of the synthesised butenediamides (MIC) μM.
| Compound | C. albicans (ATCC90028) | C. albicans (ATCC10231) | C. krusei (ATCC6258) | C. parapsilosis (ATCC22019) |
| 3a | 44.6 ± 0.57 | 44.6 ± 1.21 | 178.5 ± 0.36 | 44.6 ± 0.46 | 3b | — | — | — | — | 3c | 40.3 ± 0.48 | 80.6 ± 0.42 | 161.2 ± 1.61 | 20.2 ± 0.39 | 3d | 159.2 ± 0.45 | 159.2 ± 0.60 | 159.2 ± 0.51 | 159.2 ± 0.41 | 3e | 636.8 ± 0.64 | 636.8 ± 2.55 | 159.2 ± 0.80 | 159.2 ± 1.43 | 3f | — | — | 615.2 ± 0.65 | 615.2 ± 1.54 | 3g | 307.6 ± 0.31 | 307.6 ± 0.77 | 307.6 ± 0.40 | 153.8 ± 2.21 | 3h | 355.7 ± 1.78 | 355.7 ± 0.75 | 177.9 ± 0.60 | 355.7 ± 0.89 | 3i | 170.0 ± 0.44 | 170.0 ± 0.41 | 170.0 ± 1.16 | 170.0 ± 0.61 | 3j | 320.4 ± 0.54 | 320.4 ± 0.51 | 640.8 ± 1.60 | 640.8 ± 1.60 | 3k | 640.8 ± 1.12 | 640.8 ± 0.80 | 640.8 ± 0.74 | 640.8 ± 0.51 | Amphotericin-B | 1.3 ± 0.60 | 1.3 ± 0.49 | 5.4 ± 0.54 | 1.3 ± 0.27 |
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All experiments were carried out in triplicate. Data reported as the mean of three experiments. Key: —: No activity.
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