Comparative Studies on Conventional and Ultrasound-Assisted Synthesis of Novel Homoallylic Alcohol Derivatives Linked to Sulfonyl Dibenzene Moiety in Aqueous Media

Table 2

Synthesis of 2-bromo-1-substituted ethanones 5a,b by bromination, and 1-substituted 2-(phenylsulfonyl) ethanones 6a–e by CuI catalyzed sulfonation as outlined in Scheme 3.

Compound	R	Ultrasonic irradiation		Stirred at room temperature
		Time (min)	Yield (%)	Time (h)	Yield (%)
5 a	Ph SO2	60	92	4	80
5b	F	30	95	3	82
6a	PhSO2	60	93	8	79
6b	F	60	94	8	83
6c	Br	60	95	8	86
6d	CH3	90	90	8	75
6e	H	60	92	8	78
6a a	PhSO2	12 h	0^a	24	0^a

^aReaction in the absence of CuI and 2,6-lutidine.