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Journal of Chemistry
Volume 2013, Article ID 406161, 7 pages
http://dx.doi.org/10.1155/2013/406161
Research Article

DNA Binding and Cleavage Activities of Na[B(Glu)(OH)2]·2H2O, Na[B(Cit)(OH)2]·2H2O, Li[B(Sal)(OH)2], and Mg[B(Sal)(OH)2]·2H2O Complexes

1Department of Biomedical Engineering, School of Engineering, Karabuk University, 78050 Karabuk, Turkey
2Department of Biochemistry, Faculty of Veterinary Medicine, Mehmet Akif Ersoy University, 15030 Burdur, Turkey
3Scientific and Technology Application and Research Center, Mehmet Akif Ersoy University, 15030 Burdur, Turkey
4Department of Chemistry, Hitit University, 19030 Corum, Turkey

Received 28 December 2012; Revised 30 April 2013; Accepted 18 June 2013

Academic Editor: George Psomas

Copyright © 2013 A. Arslantas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The interaction of some previously reported complexes Na[B(Glu)(OH)2]·2H2O, Na[B(Cit)(OH)2]·2H2O, Li[B(Sal)(OH)2], and Mg[B(Sal)(OH)2]·2H2O with cattle genomic DNA (CG-DNA) was investigated using UV absorption, viscosity measurements, and fluorescence studies. These complexes interact with DNA through the intercalative mode of binding. In addition, the DNA cleavage activity of the complexes in presence of H2O2 was determined using agarose gel electrophoresis. All complexes exhibit moderate ability of cleavage to the DNA.