Anti-Inflammatory, Analgesic Evaluation and Molecular Docking Studies of N-Phenyl Anthranilic Acid-Based 1,3,4-Oxadiazole Analogues

Table 1

In vivo anti-inflammatory activity of synthesized 1,3,4-oxadiazole analogues.

Change in paw edema volume (mL)
Groups	1 h	Percentage inhibition	2 h	Percentage inhibition	3 h	Percentage inhibition
Control	0.43±0.05	—	0.72±0.06	—	0.98±0.09	—
Diclofenac sodium (10 mg/kg)	0.25±0.03	57.13	0.30±0.02	58.33	0.26±0.01	73.46
4a (100 mg/kg)	0.40±0.05	6.97	0.61±0.08	15.28	0.69±0.06	29.59
4b (100 mg/kg)	0.39±0.01	9.30	0.60±0.06	16.66	0.59±0.04	39.79
4c (100 mg/kg)	0.38±0.05	11.6	0.48±0.04	33.34	0.45±0.03	54.08
4d (100 mg/kg)	0.36±0.01	16.27	0.52±0.03	27.78	0.49±0.04	50
4e (100 mg/kg)	0.29±0.02^∗	32.55	0.38±0.04^∗	47.23	0.31±0.02^∗	68.36
4f (100 mg/kg)	0.34±0.05	20.9	0.43±0.03^∗	40.28	0.36±0.06^∗	63.26
4g (100 mg/kg)	0.36±0.05	16.27	0.55±0.02	23.61	0.55±0.05	43.87
4h (100 mg/kg)	0.35±0.01	18.6	0.46±0.02	36.12	0.44±0.03	53.10

All values are expressed as means ± SEM (𝑛=6), *𝑃<0.05 versus control.