Anti-Inflammatory, Analgesic Evaluation and Molecular Docking Studies of N-Phenyl Anthranilic Acid-Based 1,3,4-Oxadiazole Analogues

Table 2

Analgesic activity of synthesized 1,3,4-oxadiazole analogues.

Reaction time (sec.)
Groups	(After 30 min)	(After 60 min)	(After 120 min)
Control	5.43±1.7	5.29±0.9	6.30±1.2
Diclofenac sodium (10 mg/kg)	5.07±1.6	10.60±2.0	18.83±2.4
4a (100 mg/kg)	4.17±0.9	6.46±0.02	9.42±1.9
4b (100 mg/kg)	5.80±1.4	6.07±0.02	8.27±2.4
4c (100 mg/kg)	5.83±1.6	8.61±0.08	11.35±1.6
4d (100 mg/kg)	4.42±0.7	7.60±0.06	10.32±2.0
4e (100 mg/kg)	5.87±1.1	10.34±0.09^∗	15.37±2.0^∗
4f (100 mg/kg)	4.72±1.0	9.57±0.01^∗	13.28±1.6^∗
4g (100 mg/kg)	5.67±0.8	7.44±0.05	10.03±2.5
4h (100 mg/kg)	4.56±1.1	6.11±0.08	9.30±2.3

All values are expressed as means ± SEM (𝑛=6), *𝑃<0.05 versus control.