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Journal of Chemistry
Volume 2013, Article ID 430459, 10 pages
http://dx.doi.org/10.1155/2013/430459
Research Article

Fabrication of Heparinized Mesoporous Silica Nanoparticles as Multifunctional Drug Carriers

The First Affiliated Hospital, Xinxiang Medical University, Xinxiang 453100, China

Received 28 January 2013; Accepted 1 March 2013

Academic Editor: Yufang Zhu

Copyright © 2013 Yongxiang Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In this study, heparinized multifunctional mesoporous silica nanoparticles were successfully synthesized and characterized. The new material not only maintains intrinsic functions of bare magnetic and fluorescent mesoporous silica materials such as targeting, imaging, and sustained release of drugs, but also generates several novel activities such as the enhancement of biocompatibility, selective loading drugs, and dual loading of anticancer drug and bFGF, rendering it a promising candidate to be used as a multifunctional carrier. The strategy of combination of multifunctional mesoporous silica materials with bioactive molecules could be a new effective approach to improve their capabilities in the drug delivery.