Fabrication of Heparinized Mesoporous Silica Nanoparticles as Multifunctional Drug Carriers

Figure 5

(a) Release profile of DOX from MFMSNs-HP (pH = 7.4). (b) Fluorescence spectra of bFGF in the absence/presence of MFMSNs-HP: free bFGF (2 μM, 1 mL) (A), bFGF (2 μM) + 10, 20, and 30 μL of MFMSNs-HP (10 mg mL⁻¹) (B, C, D). (c) Fluorescence spectra of DOX in the absence/presence of bFGF: free DOX (1 nmol, 1 mL (A), 2 nmol, 1 mL (D)), DOX-loaded MFMSNs-HP (0.5 mg mL⁻¹, 1 mL) + 10 and 20 μL of bFGF (100 μM) (B, C).

(a)

(b)

(c)