Extractive Spectrophotometric Method for the Determination of Lamivudine and Zidovudine in Pharmaceutical Preparations Using Bromocresol Purple

Table 3

Determination of LVD and ZVD in dosage forms by the proposed and reference methods.

Statistical value	LVD		ZVD
	Proposed method^a	Reference method [7]	Proposed method^b	Reference method [6]
Mean^c	100.12	100.13	249.57	249.93
Recovery (%)	100.12	100.13	99.83	99.97
RSD (%)	0.15	0.198	0.33	0.15
𝑡-test of significance^d	0.003		0.0088
𝐹-test of significance^d	1.72		0.209

aZeffix (containing 100 mg of lamivudine per tablet).
^bRetrovir (containing 250 mg of zidovudine) per capsules.
^cFive independent analyses.
^d𝑃 = 0.05, 𝑡=2.23, 𝐹=5.05.