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Journal of Chemistry
Volume 2013 (2013), Article ID 517420, 8 pages
Research Article

Synthesis and In Vitro Antioxidant Evaluation of New 1,3,5-Tri- { 2-methoxy-4-[(4,5-dihydro-1 𝐻 -1,2,4-triazol-5-on-4-yl)-azomethine]-phenoxycarbonyl } -Benzene Derivatives

Department of Chemistry, Kafkas University, 36100 Kars, Turkey

Received 18 February 2012; Revised 3 May 2012; Accepted 12 June 2012

Academic Editor: Brijesh Tiwari

Copyright © 2013 H. Yuksek et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Nine new 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives were synthesized and characterized by elemental analyses and IR, 1H-NMR, 13C-NMR and UV spectral data. The synthesized compounds were analyzed for their in vitro potential antioxidant activities in three different methods. Those antioxidant activities were compared to standard antioxidants such as BHA, BHT and 𝛼 -tocopherol. Compounds 4e, 5a and 5d showed best activity for iron binding. In addition, the compounds 4 were titrated potentiometrically with tetrabutylammonium hydroxide (TBAH) in four non-aqueous solvents (isopropyl alcohol, tert-butyl alcohol, acetone and N,N-dimethyl formamide). Thus, the half-neutralization potential values and the corresponding p 𝐾 a values were determined in all cases.