Journal of Chemistry / 2013 / Article / Tab 1

Research Article

Validated Spectrophotometric Methods for the Determination of Mycophenolate: An Anti-Neoplastic Agent in Bulk and Pharmaceutical Dosage Forms

Table 1

Optical characteristics and validation parameters of Mycophenolate.

ParametersMethod AMethod BMethod C

Beer-Lambert’s range (μg/mL)1–1501–1501–150
𝜆 m a x /wavelength range (nm)250258240–260
Molar absorptivity (L/mol·cm) 9 . 7 1 × 1 0 3 7 . 3 7 × 1 0 2 4 . 6 8 × 1 0 4
Sandell’s sensitivity (μg cm2/0.001 absorbance unit)0.05
Slope0.0220.0010.107
Standard deviation of slope0.02520.00020.0036
Intercept0.0010.0000.025
Standard deviation of intercept0.00030.0000.0025
Correlation coefficient0.9990.9990.999
Precision (RSD, %)
Intraday ( 𝑛 = 3 )0.61–1.250.78–0.900.92–1.11
Interday ( 𝑛 = 3 )0.96–1.090.66–1.120.87–1.04
Accuracy (% recovery) (% RSD)99.87–101.80 (0.23)98.56–100.54 (0.41)99.75–100.90 (0.38)

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