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Journal of Chemistry
Volume 2013, Article ID 530135, 9 pages
http://dx.doi.org/10.1155/2013/530135
Research Article

Synthesis, Antimicrobial, and Antioxidant Activities of N-[(5′-Substituted-2′-phenyl-1H-indol-3′-yl)methylene]-5H-dibenzo[b,f]azepine-5-carbohydrazide Derivatives

1Department of Post-Graduate Studies and Research in Chemistry, Gulbarga University, Gulbarga, Karnataka 585 106, India
2Shri Prabhu Arts, Science & J M. Bohra Commerce College, Shorapur, Karnataka 585 224, India

Received 30 May 2013; Revised 26 August 2013; Accepted 28 August 2013

Academic Editor: Hasim Kelebek

Copyright © 2013 Anand R. Saundane et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The main aim of the present study was to synthesize new leads with potential antimicrobial and antioxidant activities. As a part of systematic investigation of synthesis and biological activity, some new indole compounds 3ac and 4ac were prepared and screened for their antimicrobial and antioxidant activities. The antimicrobial evaluation of newly synthesized compounds was carried out by cup-plate method. Antimicrobial activity results revealed that compound 4a showed promising activity against bacteria Staphylococcus aureus, Klebsiella pneumonia, and Pseudomonas aeruginosa and exhibited maximum inhibition against Aspergillus niger, Aspergillus oryzae, Aspergillus terreus, and Aspergillus flavus. The antioxidant activity was performed by three methods, namely, radical scavenging activity (RSA), ferric ions (Fe+3) reducing antioxidant power (FRAP), and metal chelating activity by using Hatano’s, Oyaizu’s, and Dinis' methods, respectively. Compound 4a showed promising RSA, FRAP, and metal chelating activity.