Journal of Chemistry / 2013 / Article / Tab 1

Research Article

Molecular Iodine: A Powerful Catalyst for the Knoevenagel Condensation of Isatins with Malononitrile

Table 1

Optimization studies of the condensation of isatin with malononitrilea.

EntryI2 (mol%)SolventTemp. (°C)Time (min)Yield (%)b

110CH3CN601072
210PhMe603056
310THF602080
410CHCl3602071
510MeOH60586
610EtOH60597
710EtOH256059
815EtOH60596
95EtOH601076
100EtOH6012032

aReaction conditions: isatin (1 mmol); malononitrile (1 mmol).
bIsolated yield.

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