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Journal of Chemistry
Volume 2013, Article ID 543815, 9 pages
Research Article

Synthesis, Antioxidant, Antimicrobial, Antimycobacterial, and Cytotoxic Activities of Azetidinone and Thiazolidinone Moieties Linked to Indole Nucleus

Department of Postgraduate Studies and Research in Chemistry, Gulbarga University, Gulbarga 585 106, India

Received 29 June 2012; Revised 20 August 2012; Accepted 3 October 2012

Academic Editor: Marco Radi

Copyright © 2013 A. R. Saundane and Prabhaker Walmik. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


2-N-(2-Phenyl-1H-indol-3-yl)imino-4-arylthiazoles (3ac) were used as key synthons for the preparation of (4-arylthiazol-2-yl)-4-(2-phenyl-1H-indol-3-yl)azetidin-2-ones (4ac) and 3-(4-arylthiazol-2-yl)-2-(2-phenyl-1H-indol-3-yl)thiazolidin-4-ones (5ac). These newly synthesized compounds have been characterized with the help of IR, 1H NMR, 13C NMR, and mass spectral studies. All compounds were screened for their antioxidant, antimicrobial, antimycobacterial, and cytotoxic activities. Some of the compounds displayed excellent activity.