Exploring QSAR for Antimalarial Activities and Drug Distribution within Blood of a Series of 4-Aminoquinoline Drugs Using Genetic-MLR

Table 10

Multivariate linear regression models and statistical parameters for 3D7 and W2 strains.

Log (1/IC50)	Equation	𝑅^2	𝑅^2adj	RMSE	𝐹	𝑄^2	𝑄^2𝐿5𝑜
3D7	−13.327 (1.632) + 0.236 (0.028) RDF020u + 0.280 (0.069) Mor06m + 13.883 (2.181) R8u+ + 63.224 (12.011) Gu − 5.649 (1.022) HATS5u	0.94	0.92	0.14	44.81	0.86	0.87
W2	−93.816 (12.475) + 0.131 (0.014) RDF040m + 1.285 (0.204) H4u + 86.388 (12.118) MATS6m − 1.021 (0.201) Mor16u − 2.177 (0.581) Mor32v	0.94	0.91	0.16	44.43	0.86	0.77