Exploring QSAR for Antimalarial Activities and Drug Distribution within Blood of a Series of 4-Aminoquinoline Drugs Using Genetic-MLR

Table 12

Multivariate linear regression models and statistical parameters for blood-to-plasma concentration ratio.

log 𝑅𝑏	Equation	𝑅^2	𝑅^2adj	RMSE	𝐹	𝑄^2	𝑄^2𝐿5𝑜
B/P, (1 μM)	0.948 (0.140) − 0.013 (0.002) RDF065u − 33.174 (6.778) GATS8m − 0.055 (0.007) RDF090m + 4.018 (0.582) R2u+ + 0.305 (0.104) Mor24m	0.92	0.89	0.04	32.69	0.84	0.85
B/P, (10 μM)	−21.744 (6.135) − 3.861 (0.431) R3m + 0.033(0.008) RDF095m + 28.454 (5.396) G3p − 9.616 (2.220) R4m+ + 20.931 (6.131) MATS4m	0.87	0.83	0.10	20.55	0.74	0.80