Validation of Quetiapine Fumarate in Pharmaceutical Dosage by Reverse-Phase HPLC with Internal Standard Method

Table 11

Comparison study of various methods with present analytical work.

Reference number	Detector	Type of analysis	Column	Other details
[8]	HPLC-UV	Internal standard	C8 (150×4.6 mm 5 μm)	Range: 4–400 ng mL^−1; triprolidine was used as the internal standard. Solid-phase extraction
[9]	HPLC-UV	Related impurities	Agilent XDB-C18, 50×4.6 mm	Range: LOQ to 150% of test concentration.
[16]	LC-MS/MS	NA	Luna C18 columns (50 mm × 2.0 mm, 5 μm)	Range: 0.70–500 ng/mL liquid-liquid extraction technique.
[19]	LC-MS-MS	Internal standard	Oasis-HLB	Range: 1.0 to 382.2 ng/mL, solid phase extraction
Present study	HPLC-UV	Internal Standard	Genesis-Grace C18,50×4.6,3 μm	Range: 2.01 to 50 μm/mL