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Journal of Chemistry
Volume 2013, Article ID 612756, 11 pages
http://dx.doi.org/10.1155/2013/612756
Research Article

Nucleosides 8 [18]: Ribosylation of Fused Quinazolines—Synthesis of New [1,2,4]Triazolo[5,1-b]- and [1,2,4]Triazino[3,2-b]quinazoline Nucleosides of Fluorescence Interest

1Department of Chemistry, Faculty of Science (Girls), Taif University, P.O. Box 58, Taif, Saudi Arabia
2Department of Chemistry, Faculty of Science, Taif University, Taif 888, Saudi Arabia
3Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt
4Department of Chemistry, Faculty of Science, Kafr El-Sheikh University, Kafr El-Sheikh City, Egypt

Received 3 December 2012; Revised 29 January 2013; Accepted 7 February 2013

Academic Editor: Hakan Arslan

Copyright © 2013 Laila Mohamed Break et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

[1,2,4]Triazolo[5,1-b]- and [1,2,4]triazino[3,2-b] quinazolines have been ribosylated by coupling with 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose and by using the silylation method, followed by debenzoylation by methanolic sodium methoxide to afford the corresponding free N-nucleosides. Nucleosides obtained have been identified by their spectral analysis. From the UV-visible and fluorescence studies of some nucleosides synthesized, it is found that they have fluorescence properties.