Research Article
Synthesis and Antidepressant Activity of Some New 5-(1H-Indol-3-yl)-3-(substituted aryl)-4,5-dihydroisoxazoline Derivatives
Scheme 1
Synthetic route for the synthesis of target compounds (3a–3n). Reagents and conditions: (a) DMF, POCl3; (b) piperidine, ethylene glycol, mw, 420 W, 10 min, target temperature 100°C; (c) hydroxylamine hydrochloride, EtOH, AcOH, mw, 455 W, 35 min, target temperature 95–98°C.
