Synthesis and Antidepressant Activity of Some New 5-(1H-Indol-3-yl)-3-(substituted aryl)-4,5-dihydroisoxazoline Derivatives

Table 2

Effect of 5-(1H-Indol-3-yl)-3-(substituted aryl)-4,5-dihydroisoxazoline series of compounds in forced swim test and locomotor activity.

Sr. no.	Compounds	Duration of immobility^a (sec.); (mean ± SEM)	Percentage decrease in immobility duration; (% DID)	Locomotor activity scores for 10 minutes (sec.); (mean ± SEM)
1	3a	35.7 ± 4.3***	62.2	470 ± 16.0^ns
2	3b	56.3 ± 2.0***	40.4	490 ± 9.0^ns
3	3c	26.2 ± 2.8***	72.3	480 ± 17.0^ns
4	3d	11.3 ± 0.5***	88.0	480 ± 13.0^ns
5	3e	23.7 ± 1.1***	75.0	460 ±13.0^ns
6	3f	40.2 ± 4.1***	57.5	450 ± 14.0^ns
7	3g	50.7 ± 4.2***	46.4	430 ± 29.0^ns
8	3h	27.5 ± 0.9***	70.9	410 ± 28.0^ns
9	3i	68.5 ± 4.6***	27.5	470 ± 18.0^ns
10	3j	12.5 ± 0.9***	86.8	470 ± 8.4^ns
11	3k	72.5 ± 4.5***	23.3	450 ± 17.0^ns
12	3l	54.3 ± 4.4***	42.5	460 ± 17.0^ns
13	3m	33.2 ± 5.7***	64.9	410 ± 26.0^ns
14	3n	29.3 ± 2.1***	69.0	460 ± 17.0^ns
15	Vehicle	94.5 ± 3.3	0.0	510 ± 15
16	Imipramine (20 mg/kg)	23.2 ± 0.9***	75.5	490 ± 14^ns
17	Fluoxetine (20 mg/kg)	21.3 ± 0.6***	77.4	470 ± 11^ns

^aData analyzed by one-way ANOVA followed by Dunnett’s test. n = 6; dose = 100 mg/kg. Values are represented as mean ± S.E.M. Values are significant at ***P < 0.001, compared with control group. ns: not significant (P < 0.05) as compared to vehicle-treated group.