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Journal of Chemistry
Volume 2013, Article ID 640936, 8 pages
Research Article

An Efficient Green Procedure for Synthesis of Some Fluorinated Curcumin Analogues Catalyzed by Calcium Oxide under Microwave Irradiation and Its Antibacterial Evaluation

Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University, Annamalainagar, Tamil Nadu 608 002, India

Received 15 May 2013; Accepted 25 July 2013

Academic Editor: Maolin Guo

Copyright © 2013 S. Elavarasan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A series of fluorine substituted curcumin analogues have been synthesized in a cheaper and greener method using calcium oxide as catalyst under microwave irradiation. All the synthesized compounds have been characterized by FT-IR, MS, elemental analysis, and 1H and 13C NMR spectroscopic techniques and screened for antibacterial activities against Staphylococcus aureus, β-Heamolytic streptococcus, Shigella flexneri, Vibrio cholerae, Pseudomonas aeruginosa, and Klebsiella pneumonia. All the synthesized compounds are showing good zone of inhibition against the tested bacterial strains.