Journal of Chemistry

Research Article

An Efficient Green Procedure for Synthesis of Some Fluorinated Curcumin Analogues Catalyzed by Calcium Oxide under Microwave Irradiation and Its Antibacterial Evaluation

Table 5

In vitro antibacterial activity of compounds 1–5 by disc diffusion method.
MicroorganismsCompound 1Compound 2Compound 3Compound 4Compound 5
100 ppm200 ppm500 ppm100 ppm200 ppm500 ppm100 ppm200 ppm500 ppm100 ppm200 ppm500 ppm100 ppm200 ppm500 ppm
Staphylococcus aureus ++++++++++++++++++++++++++++++++++++++++
-Heamolytic streptococcus ++++++++++++++++++++++++++++++++++++++
Shigella  flexneri ++++++++++++++++++++++++++++++++++++++++++
Vibrio  cholerae ++++++++++++++++++++++++++++++++++++++
Pseudomonas aeruginosa ++++++++++++++++++++++++++++++++++++++++++++
Klebsiella pneumoniae +++++++++++++++++++++++++++++++++++++
(−): inactive, (+): weakly active (12–16 mm), (++): moderately active (17–21 mm), (+++): strong active (22–29 mm), and (++++): highly active (30–33 mm).
At 500 ppm concentration, standard antibacterial drug, ciprofloxacin, exhibits  mm zone of inhibition against all the test bacterial strains.