Journal of Chemistry / 2013 / Article / Tab 1

Research Article

Synthesis and Evaluation of Some New Thiazolidin-4-One Derivatives as Potential Antimicrobial Agents

Table 1

Spectral and analytical data of the title compounds (7a-l).

Compound R Molecular formula Mol. wt. Yield (%) MP (°C)Elemental analysis Calcd./(found) IR (KBr, cm−1)
CHN

7a–HC17H15N6O2S34327296–9847.21 (47.14)3.73 (3.80)19.43 (19.38)3334 (NH), 2465 (S–H), 1742, 1728 (both C=O), 1620 (C=N str.), 1591 (C=C str.), 1349 (C–N), 688 (C–S–C str.)
7b2-OH–C17H16N6O3S344865195-194
45.52 (45.44)3.60 (3.65)18.74 (18.82)3292 (Ph–OH Str.), 3234 (NH), 2460 (S–H), 1720, 1700 (both C=O), 1628 (C=N str.), 1598 (C=C str.), 1351 (C–N), 689 (C–S–C str.)
7c4-Cl–C17H15N6O2S2Cl46765120–122
43.72 (43.67)3.24 (3.28)18.00 (18.07)3290 (NH), 2458 (S–H), 1720, 1695 (both C=O), 1622 (C=N), 1600 (C=C str.), 1350 (C–N), 760 (C–Cl), 690 (C–S–C str.)
7d3-NO2C17H15N7O4S247768208–210
42.76 (42.71)3.17 (3.22)20.53 (20.57)3360 (NH), 2444 (S–H), 1700, 1689 (both C=O), 1610 (C=N str.), 1523 (–NO2 str), 1352 (C–N), 709 (C–S–C str.).
7e2-NO2C17H15N7O4S247770210–212
42.76 (42.68)3.17 (3.15)20.53 (20.60)3172 (NH), 2527 (S–H), 1740, 1700 (both C=O str.), 1610 (C=N str.), 1588 (C=C str.), 1520 (–NO2 str.), 1349 (C–N), 704 (C–S–C str.)
7f4-OH–C17H16N6O3S344870117–120
45.52 (45.42)3.60 (3.66)18.74 (18.78)3295 (Ph–OH Str.), 3199 (NH), 2435 (S–H), 1738, 1709 (both C=O), 1636 (C=N str.), 1585 (C=C str.), 1350 (C–N), 672 (C–S–C str.)
7g4-(CH3)2N–C19H21N7O2S347560200–202
47.98 (47.94)4.45 (4.54)20.61 (20.65)3380–3290 (bs, NH), 2460 (S–H), 1720, 1680 (both C=O), 1610 (C=N), 1588 (C=C str.), 1335 (C–N), 692 (C–S–C str.).
7h3,4,5-(OCH3)3C20H22N6O5S352257174–176
45.96 (45.92)4.24 (4.29)16.08 (16.13)3272 (NH), 2394 (S–H), 1718–1673 (both C=O), 1646 (C=N str.), 1588 (C=C str.), 1351 (C–N), 1150 (C–O–C), 689 (C–S–C str.)
7i4-OCH3C18H18N6O3S346240130–132
46.74 (46.70)3.92 (3.96)18.17 (18.21)3370–3250 (bs, NH), 2403 (S–H), 1715, 1690 (both C=O), 1620 (C=N), 1585 (C=C str.), 1340 (C–N), 1145 (C–O–C), 680 (C–S–C str.)
7j4-Br–C17H15N6O2S3Br51170188–190
39.93 (39.89)2.96 (3.00)16.43 (16.48)3175 (NH), 2366 (S–H), 1738, 1690 (both C=O str.), 1605 (C=N str.), 1578 (C=C str.), 1518 (–NO2 str.), 1349 (C–N), 701 (C–S–C str.). 512 (C–Br),
7k4-CH3C18H18N6O2S344650204–206
48.41 (48.36)4.06 (4.10)18.82 (18.86)3395–3260 (bs, NH), 2400 (S–H), 1715–1695 (both C=O), 1610 (C=N), 1581 (C=C str.), 1348 (C–N), 695 (C–S–C str.)
7l4-F–C17H15N6O2S3F45055180–182
45.32 (45.27)3.36 (3.41)18.65 (18.69)3385–3280 (bs, NH), 2430 (S–H), 1725–1695 (both C=O), 1618 (C=N), 1588 (C=C str.), 1348 (C–N), 1235 (C–F), 688 (C–S–C str.)

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.