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Journal of Chemistry
Volume 2013, Article ID 697850, 10 pages
Review Article

Boron-Fluorine Photosensitizers for Photodynamic Therapy

Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Yichang, Hubei 443002, China

Received 18 May 2013; Accepted 20 August 2013

Academic Editor: Augusto C. Tome

Copyright © 2013 Liang Yao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Photodynamic therapy (PDT) has been recognized as a promising treatment for cancers and tumors, in which photosensitizer is one of the most important issues. As a class of excellent fluorescent dyes, boron-fluorine derivatives (typically 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene, BODIPY) have preferable ability of generating singlet oxygen and have been under extensive study for PDT sensitizers. In this review, we summarize the recent progress of design and applications of boron-fluorine-based photosensitizers for PDT.