Comparative Evaluation of the Antidiabetic Effects of Different Parts of Cassia fistula Linn, a Southeast Asian Plant

Table 2

Effect of oral administration of methanolic and aqueous extracts of Cassia fistula Linn bark, leaves, flower, and pods on blood glucose concentration in normal rats.

Experimental group	Blood glucose concentration (mg/dL)
	0 h	1 h	2 h	4 h	8 h
Normal control	85.3±2.4	84.0±2.4	86.3±2.1	82.3±3.5	79.8±3.4
Glibenclamide (2.5 mg/kg)	87.3±2.6	79.7±3.4	70.2±1.4^c	61.0±3.1^c	56.0±2.0^c
BME 250 mg/kg	85.7±3.2	84.5±2.4	80.8±3.4	76.3±1.7	70.3±3.3
BAE 250 mg/kg	85.3±2.6	82.0±2.0	80.0±2.4	76.7±2.8	71.0±3.1
BME 500 mg/kg	86.7±2.7	80.0±3.0	73.7±3.9^a	68.0±1.5^b	62.3±2.1^b
BAE 500 mg/kg	87.8±2.8	84.8±3.7	81.0±3.2	76.5±3.2	70.7±2.5
LME 250 mg/kg	81.3±1.7	80.0±3.0	78.3±2.7	75.0±2.8	70.5±3.9
LAE 250 mg/kg	82.3±3.3	80.3±3.3	78.7±3.1	75.5±1.9	71.7±2.4
LME 500 mg/kg	84.1±2.5	80.0±3.0	76.2±3.4	71.5±3.1^a	65.3±2.0^b
LAE 500 mg/kg	86.0±3.6	83.3±2.5	81.5±2.6	76.3±2.7	70.2±3.2
FME 250 mg/kg	87.1±2.7	84.7±3.4	82.0±2.0	75.8±2.5	71.3±2.4
FAE 250 mg/kg	82.5±2.8	83.3±2.7	79.2±2.1	76.2±1.2	70.2±2.2
FME 500 mg/kg	80.0±1.5	79.2±2.7	78.4±4.8	74.7±2.1	73.5±2.7
FAE 500 mg/kg	86.2±2.5	84.8±3.8	83.3±3.5	79.0±3.2	74.0±2.7
PME 250 mg/kg	85.8±3.5	83.3±1.1	83.7±1.8	80.3±3.3	85.7±3.2
PAE 250 mg/kg	84.0±2.7	83.3±3.3	82.9±3.2	79.0±2.1	85.7±3.2
PME 500 mg/kg	83.3±2.7	80.2±3.4	79.3±1.9	76.0±2.7	85.7±3.2
PAE 500 mg/kg	82.0±2.5	80.3±1.3	78.3±2.6	76.3±2.2	85.7±3.2

Values are mean ± SEM (𝑛=6). 𝑃 value: ^a<0.05, ^b<0.01, ^c<0.001 as compared with normal control group (by one-way ANOVA followed by Dunnett’s multiple comparison test).