Comparative Evaluation of the Antidiabetic Effects of Different Parts of Cassia fistula Linn, a Southeast Asian Plant

Table 3

Effect of repeated administration of methanolic and aqueous extracts of bark, leaf, and flower of Cassia fistula on glucose level in STZ-nicotinamide induced diabetic animals.

Experimental group	Blood glucose concentration (mg/dL)
	Initial concentration	Diabetic rats
		0	7	14	21
Normal control	76.58±1.5	75.26±1.82	74.43±1.74	76.59±1.8	77.46±1.74
Diabetic control	84.5±1.8	216.3±3.7	218.4±4.20	214.5±4.20	218.2±6.21
Glibenclamide	80.4±2.6	213.7±4.1	175.5±5.05^b	155.5 ± 5.04^c	146.1 ± 5.71^c
BME 250 mg/kg	76.7±2.3	216 ± 3.8	200.6±4.51	186.6 ± 4.64^b	185.7 ± 4.64^b
BAE 250 mg/kg	77.5±1.8	213 ± 4.0	208.7±4.29	199.5±4.34	191.5 ± 4.26^a
BME 500 mg/kg	76.9±1.6	213.2±4.2	193.8 ± 3.90^a	169.4 ± 3.89^c	158.9 ± 3.89^c
BAE 500 mg/kg	82.8±3.4	214.5±4.1	205.7±6.06	190.8 ± 5.83^b	189.7 ± 5.79^a
LME 250 mg/kg	77.7±3.1	213.7±3.1	207.9±8.60	194.7 ± 4.64^a	189.7 ± 4.65^a
LAE 250 mg/kg	76.6±2.3	214.2±4.9	212.1±5.13	198.5±4.66	190.6 ± 4.65^a
LME 500 mg/kg	75.6±3.2	217.8±3.0	198.5±5.71	177.6 ± 5.69^c	168.6 ± 5.68^c
LAE 500 mg/kg	77.9±1.2	215.3±4.5	209.4±4.07	201 ± 3.52	194.9±3.61
FME 250 mg/kg	84.2±2.6	212±3.0	213.1±8.62	204.2±5.01	196.2±5.01
FAE 250 mg/kg	79.2±2.2	210.5±5.0	214 ± 10.11	205.2±4.61	197.7±6.07
FME 500 mg/kg	78.4±2.6	219.8±3.8	208.5±4.94	198.4±4.98	191.4±4.97
FAE 500 mg/kg	81.8±2.6	221.3±0.7	210.9±4.92	204.9±5.05	197.8±5.05

Values are mean ± SEM (𝑛=6).
𝑃 value: ^a<0.05, ^b<0.01, ^c<0.001 as compared with diabetic control group (by one-way ANOVA followed by Dunnett’s multiple comparison test).