Journal of Chemistry / 2013 / Article / Tab 1

Research Article

RP-HPLC Analytical Method Development and Validation for Simultaneous Estimation of Three Drugs: Glimepiride, Pioglitazone, and Metformin and Its Pharmaceutical Dosage Forms

Table 1

System suitability results.

StandardAverage% RSD

Glimepiride
 Retention time5.0430.26
 Area147119330.13
 Resolution4.924
 Theoretical plates7063
 Asymmetry0.898

Pioglitazone
 Retention time3.9770.27
 Area113029360.1
 Resolution15.52
 Theoretical plates6782
 Asymmetry0.94

Metformin
 Retention time1.3420
 Area111421950.31
 Resolution0
 Theoretical plates1347
 Asymmetry1.17

Dosage form

Glimepiride
 Retention time5.0710.11
 Area147194340.1
 Resolution4.99
 Theoretical plates7142.925
 Asymmetry0.88

Pioglitazone
 Retention time3.9920
 Area11285309.50.11
 Resolution15.775
 Theoretical plates6893.845
 Asymmetry0.93

Metformin
 Retention time1.3420
 Area11109070.50.31
 Resolution0
 Theoretical plates1396.245
 Asymmetry1.205

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